Selected Recent Publications

Full publication link: PubMed

Research Articles:

1. Yi-Ru Yu, Hana Imrichova, Haiping Wang, Tung Chao, Zhengtao Xiao, Min Gao, Marcela Rincon-Restrepo, Fabien Franco, Raphael Genolet, Wan-Chen Cheng, Camilla Jandus, George Coukos, Yi-Fan Jiang, Jason W. Locasale, Alfred Zippelius, Pu-Ste Liu, Li Tang, Christoph Bock, Nicola Vannini, Ping-Chih Ho (2020) Disturbed mitochondrial dynamics rewire the epigenetic program for CD8+ TIL exhaustion. Nat. Immunol. 21; 1540-1551.

2. Haiping Wang, Fabien Franco, Yao-Chen Tsui, Xin Xie, Marcel P. Trefny, Roberta Zappasodi, Syed Raza Mohmood, Juan Fernández-García, Chin-Hsien Tsai, Isabell Schulze, Florence Picard, Etienne Meylan, Roy Silverstein, Ira Goldberg, Sarah-Maria Fendt, Jedd D. Wolchok, Taha Merghoub, Camilla Jandus, Alfred Zippelius, Ping-Chih Ho (2020) CD36-mediated metabolic adaptation supports regulatory T cell survival and function in tumors. Nat. Immunol. 21; 298-308.

3. Wan-Chen Cheng, Yao-Chen Tsui, Simone Ragusa, Marco Mina, Viktor Koelzer, Fabien Franco, Heinz Laubli, Benjamin Tschumi, Alfred Zippellius, Daniel Speiser, Pedro Romero, Tatian Petrova, Kirsten Mertz, Giovanni Ciriello, Ping-Chih Ho (2019) Uncoupling protein 2 reprograms the tumor microenvironment supporting anti-tumor immune cycle. Nat. Immunol. 20; 206-217.

4. Pu-Ste Liu, Haiping Wang, Xiaoyun Li, Tung Chao, Stefan Christen, Giusy Di Conza, Wan-Chen Cheng, Chih-Hung Chou, Magdalena Vavakova, Charlotte Muret, Koen Debackere, Massimiliano Mazzone, Hsien-Da Hung, Sarah Maria-Fendt, Julijana Ivanisevic, Ping-Chih Ho (2017) α-Ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming. Nat. Immunol. 18; 985-994.


5. *Ping-Chih Ho, Jessica Dauz Binhuniak, Andrew N. Macintyre, Matthew M. Staron, Xiaojing Liu, Robert Amezquita, Yao-Chen Tsui, Guoliang Cui, Goran Micevic, Jose C. Perales, Steven H. Klenstein, E. Dale Abel, Karl Insogna, Stefan Feske, Jason W. Locasale, Marcus W. Bosenberg, Jeffrey C. Rathmell, and *Susan M. Kaech (2015) Phosphoenolpyruvate is a metabolic checkpoint controlling Ca2+-NFAT signaling and anti-tumor T cell responses. Cell 162; 1217-1228. *is corresponding author. (Cover story)

6. *John P. Ray, *Matthew M. Staron, *Justin A. Shyer, Ping-Chih Ho, Heather D. Marshall, Simon M. Gray, Brian J. Laidlaw, Koichi Araki, Rafi Ahmed, Susan M. Kaech, and Joe Craft (2015) The interleukin-2/mTOR axis designates the reciprocal signaling, differentiation, and metabolism of T helper 1 and follicular helper T cells. Immunity 43; 690-702. * is co-first author.

7. Guoliang Cui, Matthew M. Staron, Simon M. Gray, Ping-Chih Ho, Robert Amezquita, Jingxia Wu, and Susan Kaech (2015) IL7 induces TAG synthesis through the glycerol channel aquaporin 9 to sustain memory CD8+ T cell homeostasis. Cell 161; 750-761. 

Selected Review Articles:

1. Michelangelo Certo, Chin-Hsien Tsai, Valentina Pucino, Ping-Chih Ho*, Claudio Mauro* (2020) Lactate modulation of the immune response in the inflammatory versus tumour microenvironment. Nat. Rev. Immunol. (In press) *is corresponding author.


2. Fabien Franco, Alison Jaccard, Pedro Romero, Yi-Ru Yu, Ping-Chih Ho (2020) Metabolic impairment orchestrates formation of exhausted T cells. Nat. Metab. 2; 1001-1012.

3. Haiping Wang, Chun-Hao Lu, Ping-Chih Ho (2020) Metabolic adaptation orchestrates tissue context-dependent behavior in regulatory T cells.  Immunol. Rev. 295; 126-139.

4. Xiaoyun Li, Mathias Wenes, Pedro Romero, Sarah-Maria Fendt, Stanley Ching-Cheng Huang, Ping-Chih Ho (2019) Targeting metabolic pathways to enhance anticancer immunity and immunotherapy. Nat. Rev. Clin. Oncol. 16; 425-441.

5. Pu-Ste Liu and Ping-Chih Ho (2018) Mitochondria fuel and orchestrate immune responses. Mitochondrion 41; 45-50.


6. Haiping Wang, Fabien Franco, and Ping-Chih Ho (2017) Metabolic regulation of Tregs in cancer: Opportunities for Immunotherapy. Trends in Cancer 3; 583-592. (Featured article)

7. Daniel E. Speiser, Ping-Chih Ho and Gregory Verdeil (2016) Regulatory circuits of T cell function in cancer. Nat. Rev. Immunol. 16; 599-611.

8. Ping-Chih Ho*, Pu-Ste Liu (2016) Metabolic communication in tumors: a new layer of immunoregulatoion for immune evasion. Journal for ImmunoTherapy of Cancer 4; 4-12. * is corresponding author.