Selected Recent Publications
Research Articles:
1. Haiping Wang, Fabien Franco, Yao-Chen Tsui, Xin Xie, Marcel P. Trefny, Roberta Zappasodi, Syed Raza Mohmood, Juan Fernández-García, Chin-Hsien Tsai, Isabell Schulze, Florence Picard, Etienne Meylan, Roy Silverstein, Ira Goldberg, Sarah-Maria Fendt, Jedd D. Wolchok, Taha Merghoub, Camilla Jandus, Alfred Zippelius, Ping-Chih Ho (2020) CD36-mediated metabolic adaptation supports regulatory T cell survival and function in tumors. Nat. Immunol. 21; 298-308.
2. Wan-Chen Cheng, Yao-Chen Tsui, Simone Ragusa, Marco Mina, Viktor Koelzer, Fabien Franco, Heinz Laubli, Benjamin Tschumi, Alfred Zippellius, Daniel Speiser, Pedro Romero, Tatian Petrova, Kirsten Mertz, Giovanni Ciriello, Ping-Chih Ho (2019) Uncoupling protein 2 reprograms the tumor microenvironment supporting anti-tumor immune cycle. Nat. Immunol. 20; 206-217.
3. Daniel Thommen, Viktor Koelzer, Petra Herzig, Andreas Roller, Marcel Trefny, Sarah Dimeloe, Anna Kiialainen, Jonathan Hanhart, Catherine Schill, Christoph Hess, Spasenija Savic Prince, Mark Wiese, Didier Lardinois, Ping-Chih Ho, Christian Klein, Vaios Karanikas, Kirsten Mertz, Ton Schumacher, Alfred Zippelius (2018) A transcriptionally and funcationally distinct CD8+ T cell pool with predictive potential in non-small cell lung cancer. Nat. Med. 24; 994-1004.
4. Pu-Ste Liu, Haiping Wang, Xiaoyun Li, Tung Chao, Stefan Christen, Giusy Di Conza, Wan-Chen Cheng, Chih-Hung Chou, Magdalena Vavakova, Charlotte Muret, Koen Debackere, Massimiliano Mazzone, Hsien-Da Hung, Sarah Maria-Fendt, Julijana Ivanisevic, Ping-Chih Ho (2017) α-Ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming. Nat. Immunol. 18; 985-994.
5. *Ping-Chih Ho, Jessica Dauz Binhuniak, Andrew N. Macintyre, Matthew M. Staron, Xiaojing Liu, Robert Amezquita, Yao-Chen Tsui, Guoliang Cui, Goran Micevic, Jose C. Perales, Steven H. Klenstein, E. Dale Abel, Karl Insogna, Stefan Feske, Jason W. Locasale, Marcus W. Bosenberg, Jeffrey C. Rathmell, and *Susan M. Kaech (2015) Phosphoenolpyruvate is a metabolic checkpoint controlling Ca2+-NFAT signaling and anti-tumor T cell responses. Cell 162; 1217-1228. *is corresponding author. (Cover story)
6. *John P. Ray, *Matthew M. Staron, *Justin A. Shyer, Ping-Chih Ho, Heather D. Marshall, Simon M. Gray, Brian J. Laidlaw, Koichi Araki, Rafi Ahmed, Susan M. Kaech, and Joe Craft (2015) The interleukin-2/mTOR axis designates the reciprocal signaling, differentiation, and metabolism of T helper 1 and follicular helper T cells. Immunity 43; 690-702. * is co-first author.
7. Guoliang Cui, Matthew M. Staron, Simon M. Gray, Ping-Chih Ho, Robert Amezquita, Jingxia Wu, and Susan Kaech (2015) IL7 induces TAG synthesis through the glycerol channel aquaporin 9 to sustain memory CD8+ T cell homeostasis. Cell 161; 750-761.
Selected Review Articles:
1. Haiping Wang, Chun-Hao Lu, Ping-Chih Ho (2020) Metabolic adaptation orchestrates tissue context-dependent behavior in regulatory T cells. Immunol. Rev. (In press) 298-308.
2. Xiaoyun Li, Mathias Wenes, Pedro Romero, Sarah-Maria Fendt, Stanley Ching-Cheng Huang, Ping-Chih Ho (2019) Targeting metabolic pathways to enhance anticancer immunity and immunotherapy. Nat. Rev. Clin. Oncol. 16; 425-441.
3. Yi-Ru Yu, Ping-Chih Ho (2019) Sculpting tumor microenvironment with immune system: from immunometabolism to immunoediting. Clin. Exp. Immunol. 197; 153-160.
4. Pu-Ste Liu and Ping-Chih Ho (2018) Mitochondria fuel and orchestrate immune responses. Mitochondrion 41; 45-50.
5. Haiping Wang, Fabien Franco, and Ping-Chih Ho (2017) Metabolic regulation of Tregs in cancer: Opportunities for Immunotherapy. Trends in Cancer 3; 583-592. (Featured article)
6. Daniel E. Speiser, Ping-Chih Ho and Gregory Verdeil (2016) Regulatory circuits of T cell function in cancer. Nat. Rev. Immunol. 16; 599-611.
7. Ping-Chih Ho*, Pu-Ste Liu (2016) Metabolic communication in tumors: a new layer of immunoregulatoion for immune evasion. Journal for ImmunoTherapy of Cancer 4; 4-12. * is corresponding author.